The efficiency of remote ischemic postconditioning of the myocardium in rats with induced metabolic syndrome depends on the leptin level

Remote postconditioning (RPost) has a great therapeutic potential for protecting the myocardium during ischemiareperfusion in clinical practice. At same time, an important problem limiting use of conditioning effects clinic is presence metabolic disorders patient. The aim this work was to assess effect induced syndrome (iMetS) on efficacy infarct-limiting remote ischemic rats and study mechanisms effect. carried out Wistar rats. MetS by high-carbohydrate high-fat diet. Criteria were increase weight animals, abdominal fat volume, development arterial hypertension, hypercholesterolemia, triglycerides serum, hyperleptinemia, hyperglycemia, state insulin resistance significant Homeostatic Model Assessment Insulin Resistance (HOMA-IR) index glucose tolerance. All animals subjected 45 min coronary occlusion 120 reperfusion. RPost led twofold reduction infarct size with intact metabolism ( р < 0.0001), while iMetS decrease 25 % p = 0.00003), which significantly lower than without iMetC 0.0001). A direct correlation found between serum leptin level iMetC. presented data suggested that efficiency diet-induced depends content blood.